Background Infantile spasm is a rare condition in infants from 4 to 7 months old. Treatment varies in different cases. Corticosteroids and adrenocorticotropic hormone (ACTH) are the most widely used treatment options; however, there are debates on their efficacy. The aim of our study is to compare corticosteroid treatment with ACTH in patients with infantile spasm. Materials and Me...

Although treated properly for epilepsy, a number of epileptic children have intractable seizures and about 5-10 per cent of them do not respond to anti -epileptic drugs. In the years 1986-1996 about 10,000 epileptic patients were treated in the Children's Medical Center in Tehran. A retrospective study of their medical records revealed that 41 of them had intractable seizures. I Of these 4...

PURPOSE Infantile spasm is an age-dependent epileptic syndrome seen in infancy or early childhood. Although studies have investigated the epilepsy-cytokine relationship, there has been insufficient research into the relation between cytokines and infantile spasm. The purpose of this study was to examine the role of cytokines in the pathogenesis of infantile spasm by investigating cytokine level...

although treated properly for epilepsy, a number of epileptic children have intractable seizures and about 5-10 per cent of them do not respond to anti -epileptic drugs. in the years 1986-1996 about 10,000 epileptic patients were treated in the children's medical center in tehran. a retrospective study of their medical records revealed that 41 of them had intractable seizures. i of these 4...

Objectives: to describe preliminary data referred to epileptic seizures and the probability of occurring these epileptic seizures in the infants ́ first months of life with congenital Zika virus (ZIKV) syndrome. Methods: concurrent cohort study including newborns and infants with congenital Zika virus syndrome attended at the specialized outpatient clinic at IMIP, Recife, Pernambuco, from Octobe...

Marshall Hall (1790-1857), who graduated from the University of Edinburgh's Medical School in 1812, was considered one of the greatest physiologists of his day. He advanced knowledge in various areas of medicine, in particular elucidating the mechanism of reflex activity in 1833. Hall suggested that convulsive epileptic seizures arose from heightened activity in the afferent limb or the central...

This prospective, open label, uncontrolled study was performed to evaluate the efficacy and tolerability of the modified Atkins diet in children with refractory infantile spasms. Fifteen consecutive children aged six months to three years having daily infantile spasms in clusters with electroencephalographic evidence of hypsarrhythmia despite treatment with hormonal treatment (oral corticostero...

Retrospective review was performed of children aged <3 years with epileptic spasms at our center from 2004-2010. Short-term (<6 months) and long-term (≥6 months) outcomes were assessed. We included 173 children (104 boys; median age of onset, 6.8 months) with epileptic spasms of known (62%) and unknown (38%) etiology. Treatments included adrenocorticotropic hormone (n = 103), vigabatrin (n = 82...

The present study is an investigation of anti-epileptic activity of Malachra capitata L. (FamilyMalvaceae) is a wellknown plant which is being used in Indian traditional medicines for treating epilepsy and inflammation. The aqueous extract of Malachra capitata L. (AMC) was subjected to acute toxicity and then screened for anticonvulsant activity on Maximal Electroshock (MES) and Pentylenetetraz...

OBJECTIVE The aim of this study was to evaluate the epileptic and developmental evolution in infants with West syndrome. METHODS A prospective study of 21 infants was performed, with a follow-up at 2 years. Serial assessment included long-term EEG monitoring, visual and auditory evaluation and assessment of neurodevelopment. RESULTS Neurosensory and developmental impairments at the spasm on...